Hypertrophic cardiomyopathy (HCM)
Hypertrophic cardiomyopathy thickens the heart's left ventricle wall, raising the risk of heart failure and sudden death. Ragdolls carry their own breed-specific mutation (MYBPC3 R820W, distinct from the Maine Coon's separate HCM mutation): a cat with a single copy usually shows no signs and can live a normal lifespan, but two copies bring a high risk of severe disease, typically appearing between one and two years old — so the exact genotype matters more than a simple 'tested' claim.
What to ask for
Ragdoll HCM (MYBPC3 R820W) DNA test result for both parents, stating the genotype (N/N, N/HCMrd or HCMrd/HCMrd), from UC Davis VGL or an equivalent laboratory
3 sources
- UC Davis VGL — Hypertrophic Cardiomyopathy (HCM) in Ragdolls
- Meurs et al. 2007, "A substitution mutation in the myosin binding protein C gene in ragdoll hypertrophic cardiomyopathy", Genomics
- Borgeat et al. 2014, "Association of the myosin binding protein C3 mutation (MYBPC3 R820W) with cardiac death in a survey of 236 Ragdoll cats", Journal of Veterinary Cardiology

