Hypertrophic cardiomyopathy (HCM)
A thickening of the heart muscle that can cause sudden cardiac death; Cornell's Feline Health Center lists Persian — of which the Himalayan is a colour variety — among the breeds where HCM is more prevalent than average. No specific causal DNA mutation has been established for Persian-type HCM, so a genetic test cannot rule it out.
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Cardiologist echocardiogram of both parents (no validated breed-specific DNA marker exists)

